Dimethylamine → 5-benzyloxy-2-[2-(N,N-dimethylamino)ethyl]-4-pyridone

HRID 5515

반응식

HRID 5515 반응식
[CH2:1]([O:8][C:9]1[C:10](=[O:17])[CH2:11][C:12]([CH:15]=[CH2:16])=[N:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:18][NH:19][CH3:20]>C(O)C>[CH2:1]([O:8][C:9]1[C:10](=[O:17])[CH2:11][C:12]([CH2:15][CH2:16][N:19]([CH3:20])[CH3:18])=[N:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 677480895-Benzyloxy-2-vinyl-4-pyridone

생성물 1

HCID 677480485-benzyloxy-2-[2-(N,N-dimethylamino)ethyl]-4-pyridone

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
100 °C

실험 절차

A mixture of 5-benzyloxy-2-vinyl-4-pyridone (3.12 g), 50% aqueous solution of dimethylamine (15 ml) and ethanol (35 ml) was heated at 100° C. in a sealed tube for 8 hours. The resulting mixture was cooled and concentrated under reduced pressure to dryness. The residue was triturated with a mixture of ethyl acetate and diisopropyl ether to give 5-benzyloxy-2-[2-(N,N-dimethylamino)ethyl]-4-pyridone (3.45 g) as a powder.

후처리

  1. temperatureThe resulting mixture was cooled
  2. concentrationconcentrated under reduced pressure to dryness
  3. customThe residue was triturated with a mixture of ethyl acetate and diisopropyl ether

출처 및 근거

ORD 기록
ord-7c4e570c849a48728586d884ee0e0858
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05244890

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