Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylamine → 4-(7-Bromo-3-isoquinolinyl)benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylamine | HCID 7912 | — |
| 반응물 | 4-Ethynylbenzonitrile | HCID 4547245 | — |
| 반응물 | HCID 178448919 | HCID 178448919 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4-(7-Bromo-3-isoquinolinyl)benzonitrile | HCID 67104258 | — |
반응 단계
The product from Example 62D (3.6 mmol), 4-cyanophenylacetylene (4.3 mmol), CuI (0.2 mmol), PdCl2(PPh3)2 (0.1 mmol), and diisopropylamine (5.3 mmol) can be combined in toluene (15 mL) and processed as described in Example 62E to provide the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07947711B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-b4543ed2f70449f58d2f4ed17720778e |
| 출처 메모 | uspto-grants-2011_05 |