Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperidine → (4-Isopropyl-piperazin-1-yl)-(6-piperidin-1-ylmethyl-pyridin-3-yl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | Methyl 6-formylpyridine-3-carboxylate | HCID 586269 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | Methyl 6-(piperidin-1-ylmethyl)nicotinate | HCID 44515770 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | Ammonia | HCID 222 | 1% |
| 생성물 | (4-Isopropyl-piperazin-1-yl)-(6-piperidin-1-ylmethyl-pyridin-3-yl)-methanone | HCID 11522780 | 74% |
반응 단계
6-Piperidin-1-ylmethyl-nicotinic acid methyl ester. To a solution of 6-formyl-nicotinic acid methyl ester (0.200 g, 1.21 mmol) and piperidine (0.14 mL, 1.33 mmol) in DCM (15 mL) was added NaB(OAc)3H (0.380 g, 1.80 mmol). After 18 h, the reaction was diluted with 1 N NaOH (10 mL) and extracted with DCM (2×50 mL). The organic layers were combined, dried (Na2SO4), and concentrated. Chromatography of the residue (SiO2; 1-3% 2 M NH3 in MeOH/DCM) gave the title compound as an oil (0.210 g, 74%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07947718B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-2f926d3985e946eeba310fa414bb3afc |
| 출처 메모 | uspto-grants-2011_05 |