Methyl 4-allyl-3-hydroxyoctanoate → HCID 86646127, 화합물

HRID 551631노트

반응식

HRID 551631 반응식
[CH2:1]([CH:4]([CH2:12][CH2:13][CH2:14][CH3:15])[CH:5]([OH:11])[CH2:6][C:7]([O:9]C)=[O:8])[CH:2]=[CH2:3]>[OH-].[K+].CO>[CH2:1]([CH:4]([CH2:12][CH2:13][CH2:14][CH3:15])[CH:5]([OH:11])[CH2:6][C:7]([OH:9])=[O:8])[CH:2]=[CH2:3]

참가 물질

3

반응물 1

HCID 86646126Methyl 4-allyl-3-hydroxyoctanoate

생성물 1

HCID 86646127HCID 86646127, 화합물

시약·촉매·용매 1

HCID 23689386Potassium hydroxide methanol용매

실험 절차

Methyl 4-allyl-3-hydroxyoctanoate (6.8 g, 31.7 mmol) was dissolved in a 2 N potassium hydroxide-methanol solution (20 mL), and the solution was stirred overnight at room temperature. The reaction solution was concentrated, then diluted with water, and washed with ether. The aqueous solution was made acidic using hydrochloric acid, followed by extraction with ethyl acetate. The organic layer was washed with water and saturated saline and dried over anhydrous magnesium sulfate. Then, the solvent was distilled off under reduced pressure to obtain the compound of interest as an oil substance (6.0 g, 30 mmol). This compound was used in the next reaction without being purified.

후처리

  1. concentrationThe reaction solution was concentrated
  2. additiondiluted with water
  3. washwashed with ether
  4. extractionfollowed by extraction with ethyl acetate
  5. washThe organic layer was washed with water and saturated saline
  6. dry with materialdried over anhydrous magnesium sulfate
  7. distillationThen, the solvent was distilled off under reduced pressure
  8. customto obtain the compound of interest as an oil substance (6.0 g, 30 mmol)
  9. customThis compound was used in the next reaction
  10. customwithout being purified

출처 및 근거

ORD 기록
ord-1189e0f8b36044f3973376ec231a3191
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07947738B2

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