N-methyl-2-pyrrolidone → 5-Bromo-3-[(4-fluoro-3-nitrophenyl)amino]-1-methylpyrazin-2(1H)-one

HRID 551857

반응식

HRID 551857 반응식
Br[C:2]1[C:3](=[O:10])[N:4]([CH3:9])[CH:5]=[C:6]([Br:8])[N:7]=1.[F:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][C:13]=1[N+:19]([O-:21])=[O:20].CN1CCCC1=O>C(OCC)(=O)C>[Br:8][C:6]1[N:7]=[C:2]([NH:16][C:15]2[CH:17]=[CH:18][C:12]([F:11])=[C:13]([N+:19]([O-:21])=[O:20])[CH:14]=2)[C:3](=[O:10])[N:4]([CH3:9])[CH:5]=1

참가 물질

5

반응물 3

HCID 13387N-methyl-2-pyrrolidoneHCID 677684-Fluoro-3-nitroanilineHCID 130629693,5-Dibromo-1-methyl-1H-pyrazin-2-one

생성물 1

HCID 587289745-Bromo-3-[(4-fluoro-3-nitrophenyl)amino]-1-methylpyrazin-2(1H)-one수율 69.2%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 3,5-dibromo-1-methyl-2(1H)pyrazinone (10 g; 37.5 mmol), 4-fluoro-3-nitroaniline (5.9 g; 37.5 mmol), and 1-methyl-2-pyrollidinone (30 mL) was heated at 140 degrees for 1 hr. The mixture was cooled to room temperature, diluted with ethyl acetate (100 mL) and filtered to give 5-bromo-3-(4-fluoro-3-nitro-phenylamino)-1-methyl-1H-pyrazin-2-one (1) as a yellow solid (8.9 g).

후처리

  1. temperaturewas heated at 140 degrees for 1 hr
  2. filtrationfiltered

출처 및 근거

ORD 기록
ord-6ad5f47a3b74467a818f4e4fb982d8fe
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07947835B2

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