Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 2-Cyano-6-benzyloxymethyl quinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Benzyl chloromethyl ether | HCID 137983 | — |
| 반응물 | 6-Hydroxyquinoline-2-carbonitrile | HCID 14429534 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 2-Cyano-6-benzyloxymethyl quinoline | HCID 66838503 | — |
반응 단계
To a solution of 2-cyano-6-hydroxyquinoline (100 mg) in 10 mL of acetone was added potassium carbonate (122 mg). After stirring at RT for three minutes, the solution was put on ice. Benzyl chloromethyl ether (122 μL) was added through a needle and the resultant solution was stirred on ice for 2 hours. The solvent was then removed under vacuum and the residue was purified by flash chromatography with dichloromethane. 157 mg was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07951550B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-5390042237a04690abb0a489ead1d619 |
| 출처 메모 | uspto-grants-2011_05 |