Water → ((2-Chloroethyl)thio)benzene
반응식
[C:1]1([SH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O-]CC.[Na+].Br[CH2:13][CH2:14][Cl:15].O>C(O)C>[C:1]1([S:7][CH2:13][CH2:14][Cl:15])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1참가 물질
6
실험 절차
Benzenethiol (15.0 g, 0.136 mol) was added to the solution of sodium ethoxide (0.20 mol) in 200 ml of anhydrous ethanol, and the mixture was stirred at room temperature for 15 minutes and then added to the solution of 1-bromo-2-chloroethane in 100 ml of ethanol. The resultant mixture was stirred at room temperature for 3 hours and poured into 300 ml of water. The mixture was extracted three times with ether and the combined organic layer was dried over magnesium sulfate. After removal of the solvent, the compound was purified by flash chromatography using heptane/ethyl acetate (100 to 97/3) as eluent in a yield of 74%.
후처리
- extractionThe mixture was extracted three times with ether
- dry with materialthe combined organic layer was dried over magnesium sulfate
- customAfter removal of the solvent
- customthe compound was purified by flash chromatography
출처 및 근거
- ORD 기록
- ord-815b378299de4a13abaaa97f6fcc2e5c
- 출처 데이터셋
- uspto-grants-2011_05
- 특허 번호
- US07951550B2
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