참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 6-Hydroxyquinoline-2-carbonitrile | HCID 14429534 | — |
| 반응물 | 2-Nitro-4-trifluoromethylbenzene chloride | HCID 66608264 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 6-[2-Nitro-4-(trifluoromethyl)phenoxy]quinoline-2-carbonitrile | HCID 58797699 | 35% |
반응 단계
The mixture of 2-cyano-6-hydroxyquinoline (0.50 g, 2.94 mmol), 2-nitro-4-trifluoromethylbenzene chloride (0.67 g, 2.94 mmol) and potassium carbonate (0.41 g, 2.97 mmol) in 30 ml of DMSO was heated to 100° C. for 30 min. Upon cooling to room temperature, the mixture was poured into 30 ml of cold water and exacted three times with methylene chloride. The combined organic layer was washed with water and dried over magnesium sulfate. The product was purified by flash chromatography using heptane/methylene chloride (1:2) as eluent in a yield of 35%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07951550B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_05 |
|---|
| ORD ID | ord-66f723c70bac4a4cbec8a9885b6d9ae4 |
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| 출처 메모 | uspto-grants-2011_05 |
|---|
