Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 4-Acetoxybenzyl alcohol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | Benzaldehyde, 4-(acetyloxy)- | HCID 70144 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 4-Acetoxybenzyl alcohol | HCID 95906 | 41% |
반응 단계
To the solution of 4-formylphenol acetate (6.0 g, 36.4 mmol) in 60 ml of methanol was added sodium boronhydride (1.50 g, 39.6 mmol) at 0° C. The resultant mixture was stirred for 1 hour, neutralized with acetic acid and then poured into water. The mixture was extracted three times with ether and the combined organic layer was dried over magnesium sulfate. After removal of solvent, the compound was purified by flash chromatography using heptane/ethyl acetate (80/20-70/30) as eluent in a yield of 41%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07951550B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-7ed4229d57a94f0da113cdb9686b05a9 |
| 출처 메모 | uspto-grants-2011_05 |