1-Bromo-2-Chloroethane → 1,3-Dibromo-2-(2-chloroethoxy)benzene

HRID 552075

반응식

HRID 552075 반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[C:3]=1[OH:9].C(=O)([O-])[O-].[K+].[K+].Br[CH2:17][CH2:18][Cl:19]>CN(C=O)C>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[C:3]=1[O:9][CH2:17][CH2:18][Cl:19]

참가 물질

5

반응물 3

HCID 78491-Bromo-2-ChloroethaneHCID 11430Potassium CarbonateHCID 118472,6-Dibromophenol

생성물 1

HCID 154707821,3-Dibromo-2-(2-chloroethoxy)benzene

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution comprising 2,6-dibromophenol (3.90 g, 15.00 mmol), potassium carbonate (2.48 g, 17.94 mmol) and DMF (40 ml) was added with 1-bromo-2-chloro ethane (4.30 g, 29.98 mmol) and stirred at room temperature for 16 hours. The reaction solution was concentrated and liquid separation was carried out with ethyl acetate-water. The organic layer was washed with saturated sodium chloride water and dried with anhydrous sodium sulfate. The residue obtained by concentration was purified by silica gel column chromatography (n-hexane) to obtain the target compound (4.75 g, quant.) as a colorless oily substance.

후처리

  1. concentrationThe reaction solution was concentrated
  2. customliquid separation
  3. washThe organic layer was washed with saturated sodium chloride water
  4. dry with materialdried with anhydrous sodium sulfate
  5. customThe residue obtained by concentration
  6. customwas purified by silica gel column chromatography (n-hexane)
  7. customto obtain the target compound (4.75 g, quant.) as a colorless oily substance

출처 및 근거

ORD 기록
ord-9b0bbbb9ec794185867fefed5ca2f758
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07951799B2

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