Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(4-Nitrobenzyl)piperidine → 4-(Piperidin-1-ylmethyl)aniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(4-Nitrobenzyl)piperidine | HCID 783541 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-(Piperidin-1-ylmethyl)aniline | HCID 846150 | — |
반응 단계
To a solution of 0.22 g (1.0 mmol, 1.0 eq.) of 1-(4-nitrobenzyl)piperidine (I-27) in 20 mL of THF was added ˜30 mg of Raney Nickel. The reaction mixture was stirred under at room temperature under 1 atm. of hydrogen for 12 h. The reaction mixture was through Celite® and the solvent removed in vacuo to provide 4-(piperidin-1-ylmethyl)benzenamine (I-28).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07951803B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-92dcc1ce91b347c7bc84e34fbff6c632 |
| 출처 메모 | uspto-grants-2011_05 |