Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Oxdralazine dihydrochloride → 1-(2-Dimethylamino-ethyl)-5-oxo-pyrrolidine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Oxdralazine dihydrochloride | HCID 168701 | — |
| 반응물 | Ammonium Acetate | HCID 517165 | — |
| 반응물 | 1-(2-(Dimethylamino)ethyl)-5-oxopyrrolidine-3-carboxylic acid | HCID 654521 | — |
| 반응물 | 6-Chloro-9H-beta-carbolin-8-amine | HCID 21362701 | — |
| 생성물 | 1-(2-Dimethylamino-ethyl)-5-oxo-pyrrolidine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide | HCID 11773953 | 70% |
반응 단계
Prepared according to Method B from 6-chloro-9H-β-carboline-8-ylamine and 1-(2-dimethylamino-ethyl)-5-oxo-pyrrolidine-3-carboxylic acid in 70-80% yield as the di-HCl salt. 1H-NMR (300 MHz, D2O): δ 2.97 (dd, 1H), 3.03 (s, 6H), 3.08 (dd, 1H), 3.51 (t, 2H), 3.76-3.89 (m, 3H), 3.95 (dd, 1H), 4.01 (dd, 1H), 7.75 (d, 1H), 8.24 (d, 1H), 8.45 (dd, 1H), 8.52 (dd, 1H), 9.10 (bs, 1H). Retention Time (LC, method: ammonium acetate standard): 0.99 min. MS (M+H+): 400.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07951801B2 |
| 출처 데이터셋 | uspto-grants-2011_05 |
| ORD ID | ord-f65907af9bcd4ee1a0be32454d9a9347 |
| 출처 메모 | uspto-grants-2011_05 |