Sodium Acetate → 4-(4-Propyl-piperazine-1-yl)-piperidine-1-carboxylic acid-tert-butylester

참여 물질

역할	이름	HCID	투입량
반응물	Sodium Acetate	HCID 517045	—
반응물	tert-Butyl 4-oxopiperidine-1-carboxylate	HCID 735900	—
반응물	N-Propylpiperazinium dibromide	HCID 3085288	—
반응물	Sodium cyanoborohydride	HCID 5003444	—
용매	Methanol	HCID 887	—
생성물	4-(4-Propyl-piperazine-1-yl)-piperidine-1-carboxylic acid-tert-butylester	HCID 67163983	56%

반응 조건

온도	0 °C

반응 단계

42 g (0.50 mol) sodium acetate were added in portions to 73 g (0.25 mol) N-propylpiperazine dihydrobromide in 1 l methanol at 40° C. Subsequently, this was cooled to 0° C. and 50 g (0.25 mol) Boc-4-piperidon and 16 g (0.25 mol) sodium cyanoborohydride, in portions, were added, one after the other. Everything was then stirred at room temperature for 16 h. The reaction mixture was concentrated in a vacuum and then distributed between ethyl acetate and 1M NaOH. The organic phase was separated, washed with 1M NaOH, H2O and conc. NaCl solution, dried and concentrated in a vacuum. The residue was chromatographically purified over silica gel (mobile phase: MeOH/CH2Cl2=1/15). 43.6 g of the product were obtained.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07951807B2
출처 데이터셋	uspto-grants-2011_05
ORD ID	ord-37a9e83a751c4ebd9bdbabc557cb2c63
출처 메모	uspto-grants-2011_05