Water → HCID 67166148, 화합물

HRID 552333노트

반응식

HRID 552333 반응식
[C:1]([N:4]1[CH2:21][CH2:20][C:7]2([NH:11][C:10](=[O:12])[C@H:9]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[NH:8]2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].O.C[Si]([Cl:27])(C)C>CC(CC)=O>[ClH:27].[C:1]([N:4]1[CH2:5][CH2:6][C:7]2([NH:11][C:10](=[O:12])[C@H:9]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[NH:8]2)[CH2:20][CH2:21]1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 962WaterHCID 6397ChlorotrimethylsilaneHCID 67166149HCID 67166149, 화합물

생성물 1

HCID 67166148HCID 67166148, 화합물

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

8-Acetyl-3-(S)-benzyl-1,4,8-triazaspiro[4,5]decan-2-one (300 mg, 1.0 mmol) was dissolved in ethyl methyl ketone (2 ml), treated with water (21 μL) and TMSCl (290 μL) and stirred overnight. The solid precipitated in this process was filtered off, washed with ether and dried in vacuo. The product 8-acetyl-3-(S)-benzyl-1,4,8-triazaspiro[4,5]decan-2-one hydrochloride was obtained in a yield of 330 mg (96%).

후처리

  1. customThe solid precipitated in this process
  2. filtrationwas filtered off
  3. washwashed with ether
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-89347e820dee4ebb925a917e97995dbd
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07951815B2

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