Water → HCID 67165364, 화합물
반응식
[CH2:1]([N:8]1[C:12]2([CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[NH:11][C@@H:10]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:9]1=[O:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.C[Si]([Cl:31])(C)C>CC(CC)=O>[ClH:31].[CH2:1]([N:8]1[C:12]2([CH2:13][CH2:14][NH:15][CH2:16][CH2:17]2)[NH:11][C@@H:10]([CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:9]1=[O:25])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
5
실험 절차
1,3-(S)-Dibenzyl-1,4,8-triazaspiro[4,5]decan-2-one (400 mg, 1.2 mmol) was dissolved in ethyl methyl ketone (3 ml), treated with water (12 μL) and with TMSCl (166 μL) and stirred overnight. The solid was filtered off, washed with ether and dried in vacuo. The product 1,3-(S)-dibenzyl-1,4,8-triazaspiro[4,5]decan-2-one hydrochloride was obtained in a yield of 315 mg (71%).