Ammonia → 4-Bromoisoindolin-1-one

HRID 552391노트

반응식

HRID 552391 반응식
[NH3:1].C[O:3][C:4](=O)[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Br:11])[C:6]=1[CH2:12]Br>CO>[Br:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:5]2[C:6]=1[CH2:12][NH:1][C:4]2=[O:3]

참가 물질

4

반응물 2

HCID 222Ammonia2회HCID 21907554Methyl 3-bromo-2-(bromomethyl)benzoate

생성물 1

HCID 219075094-Bromoisoindolin-1-one

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

In a 25 mL microwave tube 3-bromo-2-bromomethyl-benzoic acid methyl ester is dissolved in methanol (15 mL) and mixed with 7.0M methanolic ammonia (6.3 mL) and 17.0M aqueous ammonia (7.3 mL). The microwave tube is sealed and the mixture is stirred overnight at room temperature. The precipitate formed is filtered out and washed with cold water, then dried under vacuum to afford the title compound.

후처리

  1. customThe microwave tube is sealed
  2. customThe precipitate formed
  3. filtrationis filtered out
  4. washwashed with cold water
  5. customdried under vacuum

출처 및 근거

ORD 기록
ord-7fb216503ba340cca3edfc6422d298d0
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07951818B2

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