2-chloro-N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)ylcarbonyl)phenyl]acetamide → N-[4-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-2-(1H-[1,2,4]-triazol-1-yl)-acetamide

HRID 55249

반응식

HRID 55249 반응식
[Na].[NH:2]1[CH:6]=[N:5][CH:4]=[N:3]1.Cl[CH2:8][C:9]([NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]([N:20]2[C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=3[CH2:24][N:23]3[CH:31]=[CH:32][CH:33]=[C:22]3[CH2:21]2)=[O:19])=[CH:14][CH:13]=1)=[O:10]>CN1CCCN(C)C1=O>[CH:33]1[CH:32]=[CH:31][N:23]2[CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[N:20]([C:18]([C:15]3[CH:14]=[CH:13][C:12]([NH:11][C:9](=[O:10])[CH2:8][N:2]4[CH:6]=[N:5][CH:4]=[N:3]4)=[CH:17][CH:16]=3)=[O:19])[CH2:21][C:22]=12

참가 물질

4

반응물 2

HCID 218370752-chloro-N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)ylcarbonyl)phenyl]acetamideHCID 454898221h-1,2,4-Triazole sodium salt

생성물 1

HCID 21837048N-[4-(5H-Pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-2-(1H-[1,2,4]-triazol-1-yl)-acetamide수율 64.5%

시약·촉매·용매 1

HCID 816462(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl-용매2회

실험 절차

To a suspension of 0.20 g of 1,2,4-triazole sodium in 1 ml of 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone is added 0.10 g of 2-chloro-N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]acetamide in 1 ml of 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone followed by stirring at room temperature for 3 hours. The reaction mixture is quenched with 15 ml of water and the resulting solid is collected, washed with water and hexanes to give 70 mg of the desired product as a tan solid. MS(CI): 413(M+H).

후처리

  1. customThe reaction mixture is quenched with 15 ml of water
  2. customthe resulting solid is collected
  3. washwashed with water and hexanes

출처 및 근거

ORD 기록
ord-9322fe5a3d20426a8635e4c6b042f3ec
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05624923

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