4-Bromo-2,6-dimethylpyridine → 6,2',6'-Trimethyl-[4,4']bipyridinyl-2-carboxylic acid (2-chloro-pyridin-4-yl)-amide

HRID 552513노트

반응식

HRID 552513 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([C:11]2[CH:16]=[C:15](B3OC(C)(C)C(C)(C)O3)[CH:14]=[C:13]([CH3:26])[N:12]=2)=[O:10])[CH:5]=[CH:4][N:3]=1.Br[C:28]1[CH:33]=[C:32]([CH3:34])[N:31]=[C:30]([CH3:35])[CH:29]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([C:11]2[CH:16]=[C:15]([C:28]3[CH:33]=[C:32]([CH3:34])[N:31]=[C:30]([CH3:35])[CH:29]=3)[CH:14]=[C:13]([CH3:26])[N:12]=2)=[O:10])[CH:5]=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 130817354-Bromo-2,6-dimethylpyridineHCID 49760409N-(2-Chloropyridin-4-yl)-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-2-carboxamide

생성물 1

HCID 866145866,2',6'-Trimethyl-[4,4']bipyridinyl-2-carboxylic acid (2-chloro-pyridin-4-yl)-amide

실험 절차

The title compound, was prepared from 6-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine-2-carboxylic acid (2-chloro-pyridin-4-yl)-amide in accordance with the general method of example 131, step 2 using 4-Bromo-2,6-dimethylpyridine instead of 3-Trifluoromethyl-5-bromopyridine to yield the final compound as a white solid, MS (ISP): m/e=353.2, 355.1 (M+H)+.

출처 및 근거

ORD 기록
ord-d339f33444584908936ad71a6ae375cc
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07951824B2

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