(Pyrimidin-5-yl)boronic acid → 6-Methyl-4-pyrimidin-5-yl-pyridine-2-carboxylic acid ethyl ester

반응식

[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[C:10](Br)[CH:9]=[C:8]([CH3:13])[N:7]=1)=[O:5])[CH3:2].[N:14]1[CH:19]=[C:18](B(O)O)[CH:17]=[N:16][CH:15]=1>>[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[C:10]([C:18]2[CH:19]=[N:14][CH:15]=[N:16][CH:17]=2)[CH:9]=[C:8]([CH3:13])[N:7]=1)=[O:5])[CH3:2]

참가 물질

반응물 2

HCID 2795193(Pyrimidin-5-yl)boronic acid

HCID 25208981Ethyl 4-bromo-6-methylpicolinate

생성물 1

HCID 671644186-Methyl-4-pyrimidin-5-yl-pyridine-2-carboxylic acid ethyl ester

실험 절차

The title compound, was prepared from 4-Bromo-6-methyl-pyridine-2-carboxylic acid ethyl ester (example 1, step 4) and 5-Pyrimidineboronic acid in accordance with the general method of example 1, step 6 to yield the final compound as a white solid, MS (ISP): m/e=244.3 (M+H)+.

출처 및 근거

ORD 기록: ord-61d2225a94e6419aa9616a2984d72b6c
출처 데이터셋: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07951824B2

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