4-Thiazoleacetonitrile, 2-amino- → HCID 86614597, 화합물

반응식

C(O[C:4]([C:6]1[CH:11]=[C:10]([C:12]2[CH:13]=[N:14][CH:15]=[C:16]([F:18])[CH:17]=2)[CH:9]=[C:8]([CH3:19])[N:7]=1)=[O:5])C.[NH2:20][C:21]1[S:22][CH:23]=[C:24]([CH2:26][C:27]#[N:28])[N:25]=1>>[C:27]([CH2:26][C:24]1[N:25]=[C:21]([NH:20][C:4]([C:6]2[CH:11]=[C:10]([C:12]3[CH:13]=[N:14][CH:15]=[C:16]([F:18])[CH:17]=3)[CH:9]=[C:8]([CH3:19])[N:7]=2)=[O:5])[S:22][CH:23]=1)#[N:28]

참가 물질

반응물 2

HCID 186897514-Thiazoleacetonitrile, 2-amino-

HCID 671647705-Fluoro-6'-methyl-[3,4']bipyridinyl-2'-carboxylic acid ethyl ester

생성물 1

HCID 86614597HCID 86614597, 화합물

실험 절차

The title compound, was prepared from 5-Fluoro-6′-methyl-[3,4′]bipyridinyl-2′-carboxylic acid ethyl ester in accordance with the general method of example 26, step 6 using (2-Amino-thiazol-4-yl)-acetonitrile instead of 3-Chloroaniline to yield the final compound as a light yellow solid, MS (ISP): m/e=354.1 (M+H)+.

출처 및 근거

ORD 기록: ord-01c14c480f9c40ca9ff3d435d77d19c5
출처 데이터셋: uspto-grants-2011_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07951824B2

반응 노트

불러오는 중…