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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Diethyl Ether → (7R)-7-Amino-4-chloro-9-(2,2,2-trifluoroethyl)-6,7,9,10-tetrahydroazepino[3,4-e]indazol-8(3H)-one bis-methanesulfonate

HRID 552568
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HRID 552568 반응식
C(OC(=O)[NH:10][C@H:11]1[C:25](=[O:26])[N:24]([CH2:27][C:28]([F:31])([F:30])[F:29])[CH2:23][C:14]2[C:15]3[CH:16]=[N:17][NH:18][C:19]=3[C:20]([Cl:22])=[CH:21][C:13]=2[CH2:12]1)C1C=CC=CC=1.C1(OC)C=CC=CC=1.[CH3:41][S:42]([OH:45])(=[O:44])=[O:43].CCOCC>C(Cl)Cl>[CH3:41][S:42]([OH:45])(=[O:44])=[O:43].[CH3:41][S:42]([OH:45])(=[O:44])=[O:43].[NH2:10][C@H:11]1[C:25](=[O:26])[N:24]([CH2:27][C:28]([F:29])([F:31])[F:30])[CH2:23][C:14]2[C:15]3[CH:16]=[N:17][NH:18][C:19]=3[C:20]([Cl:22])=[CH:21][C:13]=2[CH2:12]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 6395Methanesulfonic AcidHCID 7519AnisoleHCID 59732091(R)-Benzyl 4-chloro-8-oxo-9-(2,2,2-trifluoroethyl)-3,6,7,8,9,10-hexahydroazepino[3,4-e]indazol-7-ylcarbamate

생성물 1

HCID 86640003(7R)-7-Amino-4-chloro-9-(2,2,2-trifluoroethyl)-6,7,9,10-tetrahydroazepino[3,4-e]indazol-8(3H)-one bis-methanesulfonate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a mixture of benzyl[(7R)-4-chloro-8-oxo-9-(2,2,2-trifluoroethyl)-3,6,7,8,9,10-hexahydroazepino[3,4-e]indazol-7-yl]carbamate from Step A (265 mg, 0.568 mmol) and anisole (184 mg, 1.70 mmol) in CH2Cl2 (4 mL) was added methanesulfonic acid (1.84 mL, 28 mmol). The resulting mixture was stirred at ambient temperature for 45 min, Et2O (45 mL) was added, and stirring was continued for 20 min. The supernatant was removed and the residue was washed with Et2O and dried in vacuo to give the title compound. MS: m/z=333.

후처리

  1. stirringstirring
  2. waitwas continued for 20 min
  3. customThe supernatant was removed
  4. washthe residue was washed with Et2O
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-ab5af4adb1ac466bbc1ec3bb9fbe800b
출처 데이터셋
uspto-grants-2011_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07951795B2

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