(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine → [4-(3-Methanesulfonyl-propoxy)-phenyl]-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

HRID 552583

반응식

HRID 552583 반응식
CO[C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][CH2:13][S:14]([CH3:17])(=[O:16])=[O:15])=[CH:6][CH:5]=1.[NH:19]1[CH2:23][CH2:22][CH2:21][C@H:20]1[CH2:24][N:25]1[CH2:29][CH2:28][CH2:27][CH2:26]1>>[CH3:17][S:14]([CH2:13][CH2:12][CH2:11][O:10][C:7]1[CH:6]=[CH:5][C:4]([C:3]([N:19]2[CH2:23][CH2:22][CH2:21][C@H:20]2[CH2:24][N:25]2[CH2:29][CH2:28][CH2:27][CH2:26]2)=[O:18])=[CH:9][CH:8]=1)(=[O:15])=[O:16]

참가 물질

3

반응물 2

HCID 853152(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidineHCID 597867704-(3-Methanesulfonyl-propoxy)-benzoic acid methyl ester

생성물 1

HCID 11960420[4-(3-Methanesulfonyl-propoxy)-phenyl]-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

실험 절차

The title compound is prepared in a manner substantially analogous to Procedure B and D starting from 4-(3-methanesulfonyl-propoxy)-benzoic acid methyl ester and (S)(+)-1-(2-pyrrolidinylmethyl)pyrrolidine. MS (ES+) 395.3.

출처 및 근거

ORD 기록
ord-037a999f606e49a19136046c9cb6eef4
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07951826B2

연결된 노트

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