Methyl 4-ethynylbenzoate → 3-{3-Hydroxy-6-[2-(4-methoxycarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester

HRID 55268

반응식

HRID 55268 반응식
[CH3:1][O:2][C:3](=[O:14])[CH2:4][CH2:5][C:6]1[C:11]([OH:12])=[CH:10][CH:9]=[C:8](I)[N:7]=1.[CH3:15][O:16][C:17](=[O:26])[C:18]1[CH:23]=[CH:22][C:21]([C:24]#[CH:25])=[CH:20][CH:19]=1>>[CH3:1][O:2][C:3](=[O:14])[CH2:4][CH2:5][C:6]1[C:11]([OH:12])=[CH:10][CH:9]=[C:8]([C:25]#[C:24][C:21]2[CH:22]=[CH:23][C:18]([C:17]([O:16][CH3:15])=[O:26])=[CH:19][CH:20]=2)[N:7]=1

참가 물질

3

반응물 2

HCID 640163Methyl 4-ethynylbenzoateHCID 544750193-(3-Hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester

생성물 1

HCID 541817313-{3-Hydroxy-6-[2-(4-methoxycarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester수율 59%

실험 절차

Under the conditions of example 5 A, 6.3 g of 3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester is reacted with 3.28 g of 4-ethinylbenzoic acid methyl ester, worked up, and the crude product is chromatographed on silica gel with hexane/0-50% ethyl acetate. 4.1 g of 3-{3-hydroxy-6-[2-(4-methoxycarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester of melting point 173°-177° C. is obtained.

후처리

  1. customthe crude product is chromatographed on silica gel with hexane/0-50% ethyl acetate

출처 및 근거

ORD 기록
ord-764ee4c89758482fb1e68a4452ac6320
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05624943

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