3-(6-formyl-3-methoxy-2-pyridyl)-(2E)-2-propenoic acid methyl ester → 3-(6-Hydroxymethyl-3-methoxy-2-pyridyl)-propionic acid methyl ester

반응식

[CH3:1][O:2][C:3](=[O:16])/[CH:4]=[CH:5]/[C:6]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]([CH:14]=[O:15])[N:7]=1>O1CCCC1.CO.[Pd]>[CH3:1][O:2][C:3](=[O:16])[CH2:4][CH2:5][C:6]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]([CH2:14][OH:15])[N:7]=1

참가 물질

실험 절차

Under the conditions of example 1 C, a solution of 11 g of 3-(6-formyl-3-methoxy-2-pyridyl)-(2E)-2-propenoic acid methyl ester in 140 ml of tetrahydrofuran and 40 ml of methanol in the presence of 1.2 g of 10% palladium catalyst is hydrogenated on activated carbon and worked up. 11 g of 3-(6-hydroxymethyl-3-methoxy-2-pyridyl)-propionic acid methyl ester is obtained as oily crude product, which is reacted under the conditions of example 16 E with 78 g of manganese dioxide for 21/2 hours and is worked up. 8.92 g of 3-(6-formyl-3-methoxy-2-pyridyl)-propionic acid methyl ester of melting point 95°-97° C. is obtained.