Methanol → Methyl 2-(4-bromophenyl)acetate

HRID 55295

반응식

HRID 55295 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[CH3:12]O>>[CH3:12][O:10][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=1

참가 물질

3

반응물 2

HCID 887MethanolHCID 74654Benzeneacetic acid, 4-bromo-

생성물 1

HCID 316783Methyl 2-(4-bromophenyl)acetate

실험 절차

A solution of 100 g of 4-bromophenylacetic acid in 1.5 l of methanol is mixed with 232 g of Amberlyst 15, and the suspension is stirred for 48 hours at room temperature. The reaction mixture is suctioned off on diatomaceous earth, the filter residue is washed with dichloromethane, and the filtrate is concentrated by evaporation. The residue is taken up in ethyl acetate, washed with 10% sodium bicarbonate solution and saturated common salt solution, dried on sodium sulfate and concentrated by evaporation. 106 g of 4-bromophenylacetic acid methyl ester is obtained as oil.

후처리

  1. washthe filter residue is washed with dichloromethane
  2. concentrationthe filtrate is concentrated by evaporation
  3. washwashed with 10% sodium bicarbonate solution and saturated common salt solution
  4. customdried on sodium sulfate
  5. concentrationconcentrated by evaporation

출처 및 근거

ORD 기록
ord-685cd69b188c4f41905437882c80882f
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05624943

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