Methanol → Methyl 2-(2-nitrophenyl)acetate

HRID 552997

반응식

HRID 552997 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11]([OH:13])=[O:12])([O-:3])=[O:2].S(Cl)(Cl)=O.[CH3:18]O>>[CH3:18][O:12][C:11](=[O:13])[CH2:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2]

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 77337(2-Nitrophenyl)acetic acid

생성물 1

HCID 520464Methyl 2-(2-nitrophenyl)acetate

실험 절차

A round bottom flask with magnetic stirrer was charged with (2-nitro-phenyl)-acetic acid (10.0 g, 55.0 mmol) and methanol (70 mL) under an argon atmosphere. To the resulting yellow solution at room temperature was added thionyl chloride (12.1 mL, 166 mmol) dropwise via addition funnel (Note: Reaction is very exothermic). The resulting reaction mixture was stirred at room temperature for 12-18 hours and concentrated in vacuo to afford 13.3 g of crude (2-nitro-phenyl)-acetic acid methyl ester as an orange oil. This material was used directly in subsequent reactions.

후처리

  1. additiondropwise via addition funnel (Note
  2. customReaction
  3. customThe resulting reaction mixture
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-0af16af2eab5424a91e058c0a2bfda7b
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07951950B2

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