N,N'-Diphenylformamidine → 3-methyl-2-((E)-2-phenylamino-vinyl)-1,3-bis-(3-sulfo-propyl)-3H-indolium sodium salt

HRID 553022

반응식

HRID 553022 반응식
[Na+:1].[CH3:2][C:3]1[C:11]([CH3:19])([CH2:12][CH2:13][CH2:14][S:15]([OH:18])(=[O:17])=[O:16])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N+:4]=1[CH2:20][CH2:21][CH2:22][S:23]([OH:26])(=[O:25])=[O:24].[C:27]1([NH:33][CH:34]=NC2C=CC=CC=2)[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>CO>[Na+:1].[CH3:19][C:11]1([CH2:12][CH2:13][CH2:14][S:15]([OH:18])(=[O:16])=[O:17])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N+:4]([CH2:20][CH2:21][CH2:22][S:23]([OH:26])(=[O:24])=[O:25])=[C:3]1/[CH:2]=[CH:34]/[NH:33][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

참가 물질

4

반응물 2

HCID 94888N,N'-DiphenylformamidineHCID 866399822,3-dimethyl-1,3-bis-(3-sulfo-propyl)-3H-indolium sodium salt

생성물 1

HCID 866399813-methyl-2-((E)-2-phenylamino-vinyl)-1,3-bis-(3-sulfo-propyl)-3H-indolium sodium salt

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

0.822 g (2 mmol) 2,3-dimethyl-1,3-bis-(3-sulfo-propyl)-3H-indolium sodium salt 7 and 0.49 g (2.5 mmol) N,N′-diphenyl-formamidine are dissolved in 20 ml methanol and stirred for about four hours under reflux. The solvent is removed in vacuum after cooling to room temperature. The residue is washed carefully with ethyl acetate. A dark yellow solid is obtained which is processed without further purification.

후처리

  1. temperatureunder reflux
  2. customThe solvent is removed in vacuum
  3. washThe residue is washed carefully with ethyl acetate
  4. customA dark yellow solid is obtained which
  5. customis processed without further purification

출처 및 근거

ORD 기록
ord-1fb798efe658416a8eba39e595841675
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07951959B2

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