Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Ethynylbenzoic acid methyl ester → 3-{3-Hydroxy-6-[2-(3-methoxycarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Ethynylbenzoic acid methyl ester | HCID 11275159 | — |
| 반응물 | 3-(3-Hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester | HCID 54475019 | — |
| 생성물 | 3-{3-Hydroxy-6-[2-(3-methoxycarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester | HCID 54492341 | 46.2% |
반응 단계
Under the conditions of example 5A, 9.2 g of 3-(3-hydroxy-6-iodo-2-pyridyl)-propionic acid methyl ester is reacted with 4.8 g of 3-ethinylbenzoic acid methyl ester, worked up, and the crude product is chromatographed on silica gel with hexane/0-20% ethyl acetate. 4.7 g of 3-{3-hydroxy-6-[2-(3-methoxycarbonylphenyl)-ethinyl]-2-pyridyl}-propionic acid methyl ester of melting point 125°-127° C. is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05624943 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-544f5b679e534578886630149d855777 |
| 출처 메모 | uspto-grants-1997_04 |