1,5-Diazocane → 1-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-yl]-1,5-diazacyclooctane

HRID 55317노트

반응식

HRID 55317 반응식
Br[C:2]1[N:6]([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)[C:5]2[CH:15]=[CH:16][CH:17]=[CH:18][C:4]=2[N:3]=1.[NH:19]1[CH2:26][CH2:25][CH2:24][NH:23][CH2:22][CH2:21][CH2:20]1>>[F:14][C:11]1[CH:12]=[CH:13][C:8]([CH2:7][N:6]2[C:5]3[CH:15]=[CH:16][CH:17]=[CH:18][C:4]=3[N:3]=[C:2]2[N:19]2[CH2:26][CH2:25][CH2:24][NH:23][CH2:22][CH2:21][CH2:20]2)=[CH:9][CH:10]=1

참가 물질

3

반응물 2

HCID 52483731,5-DiazocaneHCID 199575402-Bromo-1-[(4-fluorophenyl)methyl]-1H-benzimidazole

생성물 1

HCID 199575511-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-yl]-1,5-diazacyclooctane수율 108.3%

반응 조건

온도
80 °C

실험 절차

A mixture of 2-bromo-1-(4-fluorophenylmethyl)-1H-benzimidazole (10.07 g) and 1,5-diazacyclooctane (5.60 g) was heated at 80° C. for 1 hour. To the reaction mixture was added distilled water (300 ml), and the mixture was extracted with methylene chloride (300 ml). The extract was washed with water, and dried over anhydrous MgSO4. The solvent was removed under reduced pressure to give 1-[1-(4-fluorophenylmethyl)-1H-benzimidazol-2-yl]-1,5-diazacyclooctane (12.1 g) as a colorless oily liquid.

후처리

  1. additionTo the reaction mixture was added
  2. distillationdistilled water (300 ml)
  3. extractionthe mixture was extracted with methylene chloride (300 ml)
  4. washThe extract was washed with water
  5. dry with materialdried over anhydrous MgSO4
  6. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-34a5a9d5c3fc4b3aa2bbca2d61d97570
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05624948

반응 노트

불러오는 중…