Acetyl chloride → Methyl 2-(4-formylphenyl)acetate

HRID 553281노트

반응식

HRID 553281 반응식
[C:1](Cl)(=O)C.[OH:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([OH:16])=[O:15])=[CH:9][CH:8]=1>CO>[CH3:1][O:15][C:14](=[O:16])[CH2:13][C:10]1[CH:11]=[CH:12][C:7]([CH:6]=[O:5])=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 32834984-(Hydroxymethyl)phenylacetic acid

생성물 1

HCID 19363032Methyl 2-(4-formylphenyl)acetate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Acetyl chloride (5 mL) was added cautiously to solution of (4-hydroxymethylphenyl)acetic acid (5.78 g) in methanol (200 mL), stirred for 18 hours and evaporated. The residue was dissolved in dichloromethane (100 mL) and treated with manganese (IV) oxide (29.47 g), stirred for 18 hours and filtered through Celite. The filter pad was washed with dichloromethane and the combined filtrates evaporated. Purification on silica, eluting with 20% diethyl ether in iso-hexane, afforded the subtitle compound as a white solid (3.60 g).

후처리

  1. customevaporated
  2. dissolutionThe residue was dissolved in dichloromethane (100 mL)
  3. additiontreated with manganese (IV) oxide (29.47 g)
  4. stirringstirred for 18 hours
  5. filtrationfiltered through Celite
  6. washThe filter pad was washed with dichloromethane
  7. customthe combined filtrates evaporated
  8. customPurification on silica
  9. washeluting with 20% diethyl ether in iso-hexane

출처 및 근거

ORD 기록
ord-073ae94e62a74aacb8593a2d4ed65733
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07951954B2

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