Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Phenethylamine → Armodafinil
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Phenethylamine | HCID 7408 | — |
| 반응물 | Modafinil acid | HCID 3085267 | — |
| 반응물 | HCID 178514057 | HCID 178514057 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Armodafinil | HCID 9690109 | — |
반응 단계
U.S. Pat. No. 4,927,855 describes the preparation of the levorotatory enantiomer of modafinil by chiral resolution of the 2-[(diphenylmethyl)sulfinyl]acetic acid with α-methylbenzyl amine. After recovery and amidation of the enantiomerically pure acid, (−) modafinil was obtained as white crystals by crystallization from ethanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08048222B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-58141b0965b24d8e90d911acee886957 |
| 출처 메모 | uspto-grants-2011_11 |