반응식
C[C@H]1[C@@H]2CCC3(C)OO[C@]42[C@H]([C@@H](C)[C@@H](O)O[C@@H]4O3)CC1.[CH3:21][C@@H:22]1[C@H:31]2[CH2:32][CH2:33][C@@:34]3([CH3:38])[O:36][O:37][C@@:30]42[C@H:25]([C@H:26]([CH3:50])[C@H:27]([O:39][CH2:40][C:41]2[CH:42]=[CH:43][C:44]([C:47]([OH:49])=[O:48])=[CH:45][CH:46]=2)[O:28][C@@H:29]4[O:35]3)[CH2:24][CH2:23]1.ON1C2C=CC=CC=2N=N1.C(N=C=NC(C)(C)C)C>C(#N)C>[CH3:21][C@H:22]1[C@@H:31]2[CH2:32][CH2:33][C:34]3([CH3:38])[O:36][O:37][C@:30]42[C@H:25]([C@@H:26]([CH3:50])[C@@H:27]([O:39][CH2:40][C:41]2[CH:46]=[CH:45][C:44]([C:47]([OH:49])=[O:48])=[CH:43][CH:42]=2)[O:28][C@@H:29]4[O:35]3)[CH2:24][CH2:23]1참가 물질
6
반응물 4
생성물 1
시약·촉매·용매 1
실험 절차
Attempts to prepare an hydrazide derivative of artesunate were unsuccessful and resulted in the formation of dihydroartemisinin due to the cyclization reaction. Artelinate was synthesized from dihydroartemisinin as previously described (Shrimali et al. (1998) Indian J. Chem. 37B:1161-1163). Artelinic acid (0.1 g, 0.24 mmol) was dissolved in anhydrous acetonitrile (0.48 mL). To this solution, 1-hydroxybenztriazole (HOBt) (0.038 g, 0.29 mmol) was added, followed by addition of ethyl dimethylethylcarbodiimide (0.055 g, 0.29 mmol). The reaction mixture was stirred at room temperature and monitored by thin-layer chromatography (TLC) until all the acid was converted to the HOBt ester.
출처 및 근거
- ORD 기록
- ord-c3defc15bea949658fc4a5ffc314abb0
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08048850B2
연결된 노트
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