2-(N-tert-butylsulfamoyl)-N-phenylacetamide → N-phenyl-2-sulfamoylacetamide

HRID 553467노트

반응식

HRID 553467 반응식
C([NH:5][S:6]([CH2:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:11])(=[O:8])=[O:7])(C)(C)C>C(O)(C(F)(F)F)=O>[S:6]([CH2:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:11])(=[O:7])(=[O:8])[NH2:5]

참가 물질

3

반응물 1

HCID 579245132-(N-tert-butylsulfamoyl)-N-phenylacetamide

생성물 1

HCID 21435949N-phenyl-2-sulfamoylacetamide수율 96.4%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

The solution of compound 2-(N-tert-butylsulfamoyl)-N-phenylacetamide (2.5 g, 9.2 mmol.) in 40 mL of TFA was stirred at room temperature overnight. TLC analysis showed the reaction complete. Excess TFA was removed in vacuo. The value of pH was adjusted to 7-8 with NaHCO3. The mixture was extracted with EtOAc (30 mL×3). The combined organic layer was over Na2SO4, concentrated to afford compound 2-(sulfamoyl)-N-phenylacetamide (1.9 g, 96%), which was used directly without purification.

후처리

  1. customthe reaction complete
  2. customExcess TFA was removed in vacuo
  3. extractionThe mixture was extracted with EtOAc (30 mL×3)
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-f61b1478c836490cbcaeb3150c00e29a
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08048862B2

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