Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 2-(2-sulfamoylphenoxy)-N-methylacetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Hydroxybenzene-1-sulfonamide | HCID 637546 | — |
| 반응물 | 2-Bromo-N-methylacetamide | HCID 15490745 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-(2-sulfamoylphenoxy)-N-methylacetamide | HCID 57924329 | 47% |
반응 단계
To a solution of crude 1-(hydroxy)-2-sulfamoylbenzene (400 mg, 2.4 mmol.) in 60 mL of acetonitrile was added 2-bromo-N-methylacetamide (332 mg, 2.4 mmol.), K2CO3 (662 mg, 4.8 mmol.) and KI (400 mg, 2.4 mmol.). The reaction mixture was stirred at room temperature for 4 h. The reaction mixture was filtered, concentrated and purified by prep-TLC to afford 2-(2-sulfamoylphenoxy)-N-methylacetamide (260 mg, 47%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08048862B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-8bf3976ec43b4f69905ede8089b4f8b6 |
| 출처 메모 | uspto-grants-2011_11 |