Sodium triacetoxyborohydride → {2-[3'-(4-Methoxymethyl-phenyl)-2,3,5,6-tetrahydro-[1,2']bipyrazinyl-4-yl]-ethyl}-methyl-carbamic acid tert-butyl ester

Dissolve 3′-(4-methoxymethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl (1.76 g, 6.2 mmol, 1 eq.) in 1,2 dichloroethane (20 mL). Add methyl-(2-oxo-ethyl)-carbamic acid tert-butyl ester (1.13 g, 6.51 mmol, 1.05 eq.). Add sodium triacetoxyborohydride (1.97 g, 9.3 mmol, 1.5 eq.). Stir at room temperature for 18 hr. Partition the reaction mixture between aqueous saturated NaHCO3 and dichloromethane. Separate the layers. Extract the organic layer with dichloromethane (2×100 mL). Combine the organic layers, dry over anhydrous Na2SO4, filter and concentrate. Purify by normal phase chromatography with 30% EtOAc/hexane—100% EtOAc to afford the title preparation (1.01 g, 37% yield). MS (loop): m/z=442.3 [M+H].

1. customPartition the reaction mixture between aqueous saturated NaHCO3 and dichloromethane
2. customSeparate the layers
3. extractionExtract the organic layer with dichloromethane (2×100 mL)
4. dry with materialCombine the organic layers, dry over anhydrous Na2SO4
5. filtrationfilter
6. concentrationconcentrate
7. customPurify by normal phase chromatography with 30% EtOAc/hexane—100% EtOAc
8. customto afford the title
9. custompreparation (1.01 g, 37% yield)

ORD 기록

ord-9a2b2da2ec284b558f1fc7fc83adc4c8

출처 데이터셋

uspto-grants-2011_11

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08048884B2