참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 4-Bromobenzoyl chloride | HCID 68515 | — |
| 반응물 | Methyl 3-(methylamino)but-2-enoate | HCID 2734182 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Methyl acetyl(p-bromobenzoyl)acetate | HCID 603116 | — |
반응 단계
To 3-methylamino-but-2-enoic acid methyl ester (5.0 g, 39.1 mmol) in THF (70 mL) was added pyridine (3.7 mL, 47 mmol) dropwise. The mixture was cooled to 0° C., and 4-bromobenzoyl chloride (8.55 g, 39.1 mmol) in THF (30 mL) was added dropwise. The reaction was stirred at room temperature overnight, and then water was added. The mixture was extracted with EtOAc, and the combined organic layers were washed with water, dried, filtered, and concentrated to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08048902B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_11 |
|---|
| ORD ID | ord-6b5161bf103c4a3fb0b47f7e1ce1a3b0 |
|---|
| 출처 메모 | uspto-grants-2011_11 |
|---|
