Benzoic acid, 3,5-dibromo- → 1-(3,5-Dibromophenyl)ethanone

HRID 553743

반응식

HRID 553743 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:11])[CH:10]=1)[C:5]([OH:7])=O.[CH3:12][Li]>CCOCC>[Br:11][C:9]1[CH:8]=[C:4]([C:5](=[O:7])[CH3:12])[CH:3]=[C:2]([Br:1])[CH:10]=1

참가 물질

4

반응물 2

HCID 12063Benzoic acid, 3,5-dibromo-HCID 178418348HCID 178418348, 화합물

생성물 1

HCID 6218251-(3,5-Dibromophenyl)ethanone

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a solution of 3,5-dibromobenzoic acid (2.5 g, 8.9 mmol) in Et2O (30 mL) at 0° C. was added methyl lithium (1.6M in diethyl ether; 12.3 mL, 19.6 mmol) was added dropwise. The reaction was warmed to room temperature and stirred for 2 hours. Acidic work-up, followed by silica gel chromatography, gave 1-(3,5-dibromo-phenyl)-ethanone.

후처리

  1. additionwas added dropwise

출처 및 근거

ORD 기록
ord-8bd557ae417f45ce91de4786a539d9ca
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08048902B2

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