Acetyl chloride → Methyl 3-fluoro-4-nitrobenzoate
반응식
[C:1](Cl)(=O)C.[F:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[N+:15]([O-:17])=[O:16])[C:9]([OH:11])=[O:10]>CO>[F:5][C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[N+:15]([O-:17])=[O:16])[C:9]([O:11][CH3:1])=[O:10]참가 물질
4
실험 절차
To a solution prepared by the dropwise addition of 12 ml acetyl chloride to 150 ml methanol was added 7.0 grams 3-fluoro-4-nitrobenzoic acid and the resulting mixture was stirred at room temperature for 18 hours. The solvent was removed in vacuo and the residue was partitioned between ethyl acetate and 2% sodium carbonate solution. The organic layer was washed with saturated sodium chloride solution, dried over magnesium sulfate, filtered, and evaporated in vacuo to give 6 grams of methyl 3-fluoro-4-nitrobenzoate as an orange oil which gradually hardened to a yellow solid.
후처리
- customThe solvent was removed in vacuo
- customthe residue was partitioned between ethyl acetate and 2% sodium carbonate solution
- washThe organic layer was washed with saturated sodium chloride solution
- dry with materialdried over magnesium sulfate
- filtrationfiltered
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-05ac5c8e382847e08303bf53883c12df
- 출처 데이터셋
- uspto-grants-1997_04
- 특허 번호
- US05624957
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