Methyl 3-fluoro-4-nitrobenzoate → Methyl 4-amino-3-fluorobenzoate

HRID 55379노트

반응식

HRID 55379 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[N+:12]([O-])=O)[C:5]([O:7][CH3:8])=[O:6].[H][H]>C(OCC)(=O)C.[Pd]>[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[NH2:12])[C:5]([O:7][CH3:8])=[O:6]

참가 물질

5

반응물 2

HCID 592761Methyl 3-fluoro-4-nitrobenzoateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 11182865Methyl 4-amino-3-fluorobenzoate수율 99.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

In 150 ml ethyl acetate was dissolved 5.74 grams methyl 3-fluoro-4-nitrobenzoate and the resulting solution was hydrogenated in the Parr apparatus (45 psi) over 600 mg 10% Pd-on-C for about 45 minutes, when the hydrogen uptake ceased. The catalyst was removed by filtration and the solvent was removed in vacuo to give 4.86 grams methyl 3-fluoro-4-aminobenzoate as an off-white solid, m.p. 107°-110° C.

후처리

  1. customThe catalyst was removed by filtration
  2. customthe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-1425f6c613514eafb73670cedd89f5f3
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05624957

반응 노트

불러오는 중…