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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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methyl (4R*,9aS*)-6-oxo-4-(3,4,5-trifluorophenyl)-1,3,4,6,7,9a-hexahydropyrido[1,2-a]pyrazine-2-carboxylate → methyl (4R*,9aS*)-6-oxo-4-(3,4,5-trifluorophenyl)octahydropyrido[1,2-a]pyrazine-2-carboxylate

HRID 554009
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HRID 554009 반응식
[O:1]=[C:2]1[N:7]2[C@H:8]([C:16]3[CH:21]=[C:20]([F:22])[C:19]([F:23])=[C:18]([F:24])[CH:17]=3)[CH2:9][N:10]([C:12]([O:14][CH3:15])=[O:13])[CH2:11][C@@H:6]2[CH:5]=[CH:4][CH2:3]1.[H][H]>CO.[Pt]=O>[O:1]=[C:2]1[N:7]2[C@H:8]([C:16]3[CH:17]=[C:18]([F:24])[C:19]([F:23])=[C:20]([F:22])[CH:21]=3)[CH2:9][N:10]([C:12]([O:14][CH3:15])=[O:13])[CH2:11][C@@H:6]2[CH2:5][CH2:4][CH2:3]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 67463345methyl (4R*,9aS*)-6-oxo-4-(3,4,5-trifluorophenyl)-1,3,4,6,7,9a-hexahydropyrido[1,2-a]pyrazine-2-carboxylateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 67464787methyl (4R*,9aS*)-6-oxo-4-(3,4,5-trifluorophenyl)octahydropyrido[1,2-a]pyrazine-2-carboxylate

시약·촉매·용매 2

HCID 82844Platinum oxide (PtO)촉매HCID 887Methanol
용매

실험 절차

Platinum oxide (10 mg) was added to a solution of methyl (4R*,9aS*)-6-oxo-4-(3,4,5-trifluorophenyl)-1,3,4,6,7,9a-hexahydropyrido[1,2-a]pyrazine-2-carboxylate obtained by performing the above method again (292 mg) in methanol (5 mL), and the reaction solution was stirred in a hydrogen atmosphere at room temperature for three hours. The reaction solution was filtered through celite, and the filtrate was concentrated under reduced pressure to obtain 255 mg of the title compound. The property values of the compound are as follows.

후처리

  1. customobtained
  2. filtrationThe reaction solution was filtered through celite
  3. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-355aeead3eef4b49bb757af2662f82f6
출처 데이터셋
uspto-grants-2011_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08048878B2

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