Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Indole-3-Acetic Acid → (3aRS,4RS,7aRS)-7,7-dimethyl-4-(2-methoxyphenyl)-2-(3-indolylacetyl)-4-perhydroisoindolol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Indole-3-Acetic Acid | HCID 802 | — |
| 반응물 | (3aRS,4RS,7aRS)-7,7-dimethyl-4-(2-methoxyphenyl)-4-perhydroisoindolol hydrochloride | HCID 67714309 | — |
| 생성물 | (3aRS,4RS,7aRS)-7,7-dimethyl-4-(2-methoxyphenyl)-2-(3-indolylacetyl)-4-perhydroisoindolol | HCID 67713946 | 20.4% |
반응 단계
By working according to the experimental procedure of Example 6, from 0.6 g of (3aRS,4RS,7aRS)-7,7-dimethyl-4-(2-methoxyphenyl)-4-perhydroisoindolol hydrochloride and 0.4 g of 3-indoleacetic acid, and after purification on a column of silica gel (particle size 0.04-0.06 mm, diameter 2.4 cm, height 15 cm), 0.17 g of (3aRS,4RS,7aRS)-7,7-dimethyl-4-(2-methoxyphenyl)-2-(3-indolylacetyl)-4-perhydroisoindolol is obtained, in the form of a white foam.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05624950 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-cf9e5536c08644c1bc1ee6e1672ec56c |
| 출처 메모 | uspto-grants-1997_04 |