Tosylmethyl isocyanide → Methyl 4-ethyl-1H-pyrrole-3-carboxylate

HRID 554223노트

반응식

HRID 554223 반응식
C1(C)C=CC(S([CH2:10][N+:11]#[C-:12])(=O)=O)=CC=1.[C:14]([O:20][CH3:21])(=[O:19])[CH:15]=[CH:16][CH2:17][CH3:18].CC(C)([O-])C.[K+]>>[CH2:17]([C:16]1[C:15]([C:14]([O:20][CH3:21])=[O:19])=[CH:10][NH:11][CH:12]=1)[CH3:18]

참가 물질

4

반응물 3

HCID 161915Tosylmethyl isocyanideHCID 519179Methyl pent-2-enoateHCID 23665647Potassium tert-butoxide

생성물 1

HCID 53419689Methyl 4-ethyl-1H-pyrrole-3-carboxylate수율 64%

실험 절차

Using p-toluenesulfonylmethyl isocyanide (10.1 g), methyl 2-pentenoate (6.01 g) and potassium tert-butoxide (7.01 g), a procedure as in Reference Example 39 was performed to give the title compound as pale-yellow crystals (yield 5.05 g, 64%).

출처 및 근거

ORD 기록
ord-172882b642284e0bba6bb7c1b956104f
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08048909B2

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