Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 1-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-5-phenyl-1H-pyrrole-3-carbaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 15-Crown-5 | HCID 36336 | — |
| 반응물 | 2,3-Dihydro-1,4-benzodioxine-6-sulfonyl chloride | HCID 2776169 | — |
| 반응물 | 5-Phenyl-1H-pyrrole-3-carboxaldehyde | HCID 11052090 | — |
| 생성물 | 1-(2,3-Dihydro-1,4-benzodioxin-6-ylsulfonyl)-5-phenyl-1H-pyrrole-3-carbaldehyde | HCID 86620752 | 70% |
반응 단계
Using 5-phenyl-1H-pyrrole-3-carbaldehyde (171 mg), sodium hydride (60% in oil, 72 mg), 15-crown-5 (330 mg) and 2,3-dihydro-1,4-benzodioxine-6-sulfonyl chloride (352 mg), a procedure as in Reference Example 219 was performed to give the title compound as a pale-yellow oil (yield 258 mg, 70%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08048909B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-d5c0321638264409b9d78550f66cace6 |
| 출처 메모 | uspto-grants-2011_11 |