Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → Methyl 2-[(4-formyl-2-phenyl-1H-pyrrol-1-yl)sulfonyl]benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 15-Crown-5 | HCID 36336 | — |
| 반응물 | Benzoic acid, 2-(chlorosulfonyl)-, methyl ester | HCID 117830 | — |
| 반응물 | 5-Phenyl-1H-pyrrole-3-carboxaldehyde | HCID 11052090 | — |
| 생성물 | Methyl 2-[(4-formyl-2-phenyl-1H-pyrrol-1-yl)sulfonyl]benzoate | HCID 86620753 | 60% |
반응 단계
Using 5-phenyl-1H-pyrrole-3-carbaldehyde (513 mg), sodium hydride (60% in oil, 216 mg), 15-crown-5 (990 mg) and methyl 2-(chlorosulfonyl)benzoate (1.06 g), a procedure as in Reference Example 219 was performed to give the title compound as a pale-yellow oil (yield 664 mg, 60%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08048909B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-f8a88398dbfd49268796cd1c27a7937c |
| 출처 메모 | uspto-grants-2011_11 |