Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Indole-3-Acetic Acid → 4-(2-Methoxyphenyl)-7-methyl-4-perhydroisoindolol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Indole-3-Acetic Acid | HCID 802 | — |
| 반응물 | (3aRS,4RS,7SR,7aRS)-7-(hydroxymethyl)-4-(2-methoxyphenyl)-7-methyl-4-perhydroisoindolol | HCID 67714238 | — |
| 생성물 | 4-(2-Methoxyphenyl)-7-methyl-4-perhydroisoindolol | HCID 131719999 | — |
반응 단계
By working in an identical manner to Example 1, 1.5 g of (3aRS,4RS,7SR,7aRS)-7-(hydroxymethyl)-4-(2-methoxyphenyl)-7-methyl-4-perhydroisoindolol and 0.88 g of 3-indoleacetic acid are used. After concentration, the crude residue is recrystallized in acetonitrile and, after drying at 40° C. and 15 Pa, 0.7 g of (3aRS,4RS,7SR,7aRS)-7-(hydroxymethyl)-2-(3-indolylacetyl)-4-(2-methoxyphenyl)-7-methyl-4ethyl)-4-(2-methoxyphenyl)-7-methyl-4-perhydroisoindolol is obtained, in the form of a white solid melting at 170-180° C. (pasty melt).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05624950 |
| 출처 데이터셋 | uspto-grants-1997_04 |
| ORD ID | ord-99f1581b1fab49a69efa22f41c19a858 |
| 출처 메모 | uspto-grants-1997_04 |