Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → 1-[1-(Butylsulfonyl)-5-phenyl-1H-pyrrol-3-yl]-N-methylmethanamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 1-Butanesulfonyl chloride | HCID 75430 | — |
| 반응물 | Tert-butyl methyl[(5-phenyl-1H-pyrrol-3-YL)methyl]carbamate | HCID 57522146 | — |
| 생성물 | 1-[1-(Butylsulfonyl)-5-phenyl-1H-pyrrol-3-yl]-N-methylmethanamine | HCID 66924931 | 24% |
반응 단계
Using tert-butyl methyl[(5-phenyl-1H-pyrrol-3-yl)methyl]carbamate (70 mg), sodium hydride (60% in oil, 98 mg) and butane-1-sulfonyl chloride (230 mg), a procedure as in Example 38 was performed to give the title compound as pale-purplish red crystals (yield 18 mg, 21%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08048909B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-eea15db9a3b84e109d374ed1e2ba4958 |
| 출처 메모 | uspto-grants-2011_11 |