(5-Bromo-2-chloro-pyridin-3-yl)-acetic acid ethyl ester → [2-Chloro-5-(2-formyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

HRID 554610노트

반응식

HRID 554610 반응식
[CH2:1]([O:3][C:4](=[O:14])[CH2:5][C:6]1[C:7]([Cl:13])=[N:8][CH:9]=[C:10](Br)[CH:11]=1)[CH3:2].CC1(C)C(C)(C)OB([C:23]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][C:24]=2[CH:25]=[O:26])O1>>[CH2:1]([O:3][C:4](=[O:14])[CH2:5][C:6]1[C:7]([Cl:13])=[N:8][CH:9]=[C:10]([C:23]2[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][C:24]=2[CH:25]=[O:26])[CH:11]=1)[CH3:2]

참가 물질

3

반응물 2

HCID 58565158(5-Bromo-2-chloro-pyridin-3-yl)-acetic acid ethyl esterHCID 866405342-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzaldehyde

생성물 1

HCID 86640533[2-Chloro-5-(2-formyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

실험 절차

(5-Bromo-2-chloro-pyridin-3-yl)-acetic acid ethyl ester and 2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzaldehyde were reacted as described in Example 3, Step 6 to provide [2-chloro-5-(2-formyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester.

출처 및 근거

ORD 기록
ord-d0b8f0014d9e49b7b9e4951423b6ae32
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08049015B2

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