Cyclopropanecarboxylic acid → Cyclopropanecarboxylic acid [2-(5-bromo-2-methoxy-pyridin-3-yl)-5-trifluoromethyl-benzyl]-ethyl-amide

HRID 554616노트

반응식

HRID 554616 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:11]=2[CH2:12][NH:13][CH2:14][CH3:15])[C:5]([O:8][CH3:9])=[N:6][CH:7]=1.[CH:24]1([C:27]([OH:29])=O)[CH2:26][CH2:25]1>>[Br:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:21])[F:22])=[CH:16][C:11]=2[CH2:12][N:13]([CH2:14][CH3:15])[C:27]([CH:24]2[CH2:26][CH2:25]2)=[O:29])[C:5]([O:8][CH3:9])=[N:6][CH:7]=1

참가 물질

3

반응물 2

HCID 15655Cyclopropanecarboxylic acidHCID 67212358[2-(5-Bromo-2-methoxy-pyridin-3-yl)-5-trifluoromethyl-benzyl]-ethyl-amine

생성물 1

HCID 67212469Cyclopropanecarboxylic acid [2-(5-bromo-2-methoxy-pyridin-3-yl)-5-trifluoromethyl-benzyl]-ethyl-amide

실험 절차

[2-(5-Bromo-2-methoxy-pyridin-3-yl)-5-trifluoromethyl-benzyl]-ethyl-amine and cyclopropanecarboxylic acid were reacted as described in Example 8, Step 6 to provide cyclopropanecarboxylic acid [2-(5-bromo-2-methoxy-pyridin-3-yl)-5-trifluoromethyl-benzyl]-ethyl-amide.

출처 및 근거

ORD 기록
ord-0202424bd03546eb94012778efae2e02
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08049015B2

반응 노트

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