Aluminium lithium hydride → 2-(2,3-dihydro-1H-indol-1-yl)ethan-1-ol

HRID 55475노트

반응식

HRID 55475 반응식
[N:1]1([CH2:10][C:11](OC)=[O:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[N:1]1([CH2:10][CH2:11][OH:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 22199910Methyl (2,3-dihydro-1H-indol-1-yl)acetate

생성물 1

HCID 232983052-(2,3-dihydro-1H-indol-1-yl)ethan-1-ol수율 87.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A procedure similar to that described in Preparation 2 was repeated, except that 780 mg of methyl indolin1-ylacetate (prepared as described in Preparation 8), 200 mg of lithium aluminum hydride and 12 ml of anhydrous tetrahydrofuran were used, to give 580 mg of the title compound having Rf=0.31 (on silica gel thin layer chromatography using a 2:1 by volume mixture of hexane and ethyl acetate as the developing solvent).

후처리

  1. customA procedure similar to that described in Preparation 2

출처 및 근거

ORD 기록
ord-22a51bca3b2f4b4fbce4d57f55cb9f4b
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05624935

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