Aniline → n-[(1r)-1-(Anilinocarbonyl)propyl]-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-carboxamide

HRID 554786

반응식

HRID 554786 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][CH:19]([CH2:31][CH3:32])[C:20]([NH:22][CH2:23][C:24](OC(C)(C)C)=O)=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1.Cl.C(OC(=O)CN)(C)(C)C.N[C:48]1[CH:53]=CC=[CH:50][CH:49]=1>>[NH:22]([C:20]([C@H:19]([NH:18][C:16]([N:13]1[C:14](=[O:15])[CH:8]([CH2:7][C:6]2[CH:34]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=2[O:35][CH3:36])[CH2:9][NH:10][C:11](=[O:33])[CH2:12]1)=[O:17])[CH2:31][CH3:32])=[O:21])[C:23]1[CH:50]=[CH:49][CH:48]=[CH:53][CH:24]=1

참가 물질

4

반응물 3

HCID 6115AnilineHCID 2725036Glycine tert-butyl ester hydrochlorideHCID 76588771Tert-butyl {[2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}acetate

생성물 1

HCID 57670989n-[(1r)-1-(Anilinocarbonyl)propyl]-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-carboxamide

실험 절차

Instead of the starting material compound of Example 220, that is, glycine tert-butyl ester hydrochloride, aniline was used for the similar procedure as in Example 220 to obtain the title compound.

출처 및 근거

ORD 기록
ord-1a159e491cfd48188b056c5dbebf2661
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08049006B2

연결된 노트

불러오는 중…